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My only hesitation in accepting the hypothesis that obesity is a downstream effect of hypothalamic inflammation lies in the fact that, in metabolically healthy individuals, a normally functioning digestive system, a non-steatotic liver, nutrient-sensitive pancreas and intestine, insulin-sensitive adipose tissue, should mitigate, at least to some extent (though not completely), the negative effects of an unhealthy diet, until their compensatory capacity fails

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Calcium chloride (CaCl 2 ), copper chloride (CuCl 2 ), L-ascorbic acid (AA), Methylene blue (MB), and Metformin hydrochloride (MET) were purchased from Macklin Biochemical Co., Ltd (Shanghai, China)