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Lack of Ongoing Support GLP-1s only tend to work with proper use in combination with appropriate lifestyle changes advised by a provider or team of providers
Ascendis has shown proof-of-principle in preclinical animal studies for a once-monthly GLP-1 receptor agonist
In contrast, safe weight loss improves muscle insulin sensitivity which actually helps prevent muscle protein breakdown
Raising similar concerns, researchers from Denmark published a study in 2024 looking at bone density in 195 participants given the GLP-1 drug Victoza
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