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When to Add MOTS-C Add MOTS-C 2-3 weeks after you're stable on Tesamorelin: Start at 500mcg daily, morning injection (subQ) Can increase to 1mg daily after 2 weeks if tolerated Some prefer 5mg 2-3x weekly instead of daily both protocols work MOTS-C effects take 2-3 weeks to become noticeable (improved training endurance, steadier energy levels)

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Clinical studies have shown that Tirzepatide can lead to greater reductions in HbA1c (a key marker of long-term blood sugar control) and more pronounced weight loss compared to semaglutide and similar medications

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10.1093/ajh/hpt196 67

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