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These secondary hormonal perturbations are dose-dependent and more pronounced at higher concentrations
Notably, the Roux-en-Y procedure has a greater impact on MASLD than the other procedures, improving or resolving steatosis in 91% of patients and liver fibrosis in 31%
Preclinical studies have indicated that GLP1RAs, such as tirzepatide, may directly impact the vasculature by enhancing endothelial function and decreasing inflammation, which are important in preventing atherosclerosis[30]
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