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There are really fantastic research opportunities going forward to tease out these mechanisms, said Drucker, who began studying GLP-1 40 years ago

ATTAIN-MAINTAIN An innovative trial evaluating whether orforglipron can maintain weight loss previously achieved with injectable GLP-1 receptor agonists (semaglutide or tirzepatide)

Although these agents produce substantial and sustained weight reduction, emerging clinical observations suggest that chronic therapy may be accompanied by changes in lean mass trajectory, reduced protein intake, and micronutrient insufficiency

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