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It is worth mentioning that SGLT-2 inhibitor use is restricted in patients with renal failure, in which case GLP-1 receptor agonists are considered (down to an eGFR of 15 ml/ml) [68]
After a 3-year follow-up, their urinary albumin-to-creatinine ratios and estimated glomerular filtration rates remained improved, contributing to a 20% lower risk of death (12)
The risk is highest during the first 48 weeks of treatment when receptor sensitivity is still stabilizing and nausea is most pronounced
has received consulting honoraria from Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Daichii-Sankyo, Eli Lilly, esanum, Gilead, Ipsen, Novartis, Novo Nordisk, Sandoz and Sanofi, and has received research grants from AstraZeneca, Eli Lilly and Novo Nordisk
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