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The improvements in HbA1c and weight loss were also clinically meaningful, the former reflecting evidence from DCCT/EDIC 2,3 and the latter meeting the minimum weight loss (5%) needed for metabolic improvement 41
The physiological relevance of the mesolimbic GLP-1 is suggested by the demonstration that similar anorexic effects can be obtained by independent stimulation of the mesolimbic and hypothalamic GLP-1 receptors (GLP-1R)
"For a patient who needs to achieve more weight loss and who doesn't experience many side effects, perhaps this higher dose will help them achieve it," she says
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