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Originally known for its role in pregnancy testing and fertility treatments, HCG has also found applications in mens health particularly in conjunction with testo

116 In ER-positive breast cancer, PIK3CA mutations drive hormone-independent proliferation and enable cancer cells to bypass estrogen signaling

Additionally, in microglia, LRRK2 exerts a negative regulatory effect on -syn clearance by downregulating the early endocytosis pathway, as LRRK2 -knockout microglia exhibit enhanced -syn uptake and clearance associated with increased Rab5-positive early endosomes and improved Rab5-dynamin 1 coordination (195)