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Understanding MOTS-c: A Mitochondrial Maestro MOTS-c, or Mitochondrial Open Reading Frame of the 12S rRNA-c, is a fascinating mitochondrial-derived peptide composed of 16 amino acids

However, they can be more expensive and may have gastrointestinal side effects

A systematic approach helps determine whether the medication can be used or requires replacement

While our MR analysis found no genetic evidence supporting a causal protective effect of Metformin or Semaglutide on AD, this does not rule out non-genetic mechanisms, such as Metformins antiviral properties or microbiota modulation, which are not captured by MR analysis