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Seek immediate medical attention for severe persistent abdominal pain (which could suggest pancreatitis)

Patients should understand the difference between expected cold sensitivity and symptoms suggesting thyroid dysfunction, anemia, or other metabolic disorders that require investigation and management

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The cysteine-rich and glycosylated regions of DPP-4 carry out the non-enzymatic functions, involved in cell signaling, immune regulation, inflammation, and tissue remodeling (Zhong et al., 2013)