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Clinically, this resistance manifests in two distinct patterns, arising from both the progressive functional exhaustion of tumor-specific T cells and the dynamic equilibrium between immune attack and tumor evasion, which are continuously challenged within an immunosuppressive tumor microenvironment (TME) sculpted by immunoediting

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Vigorous agitation generates shear forces and an air-liquid interface that promote peptide aggregation, and it produces foam that traps material away from the solution

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