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In May 2026, Lilly reported that in a late-stage trial of adults with obesity or overweight and at least one weight-related comorbidity, the highest 12 mg dose of retatrutide produced 28.3% average weight loss over 80 weeks, and more than 45% of participants lost 30% or more of their body weight

Disclosure Professor Xiao-Yu Tian reports grants from Clinical Medical Excellence Training Program funded by government (ZF2023112), grants from the 14th Five-Year Plan Clinical Medicine Innovation Research Team of Hebei Medical University, Class B Team Project (2022LCTD-B15), grants from Hebei Provincial Health Commission Project (20230594), grants from Hebei Province Third Batch of Young Top Talents Program, outside the submitted work

Originally derived from a natural extract known as Epithalamin, Epithalon has been studied in preclinical and laboratory models as an exciting candidate in the field of biogerontology and molecular biology