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Glutathione S-transferase mediates an ageing response to mitochondrial dysfunction [PMID: 26704446] Laboratory literature summary: Glutathione S-transferase mediates an ageing response to mitochondrial dysfunction

It acted via non-competitive inhibition, binding to non-active sites and inducing structural rearrangements, with reduced -helical content and increased -sheet and random coil, thereby disrupting ACE function without active-site competition

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