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31 Hypoalbuminemia has been associated with the development and severity of pancytopenia, 25 which likely contributed to the experience of MIOM in both Case 1 and Case 5, who were elderly patients with impaired kidney function and low albumin levels, leading to reduced MTX clearance and increased MTX toxicity
In animal models, selective removal of these cells has been associated with improved tissue morphology and regenerative capacity
They are well-tolerated in advanced CKD and dialysis, though they lack the cardiovascular and kidney benefits of SGLT2 inhibitors and GLP-1 agonists
Blood or mucus in the stool
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