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Eating and Drinking to Support Movement Scientific American reports that the only way to reduce muscle loss somewhat during weight loss is to combine exercise with a higher-protein diet. The same source explains that adults normally aim for about 0.8 grams of protein per kilogram of body weight per day, but that people exercising during weight loss may need 1.21.5 grams per kilogram to preserve muscle. Hydration is also important

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The article discusses the pharmacokinetic challenges peptides face, such as low oral bioavailability due to poor membrane permeability and enzymatic degradation in the gastrointestinal tract

Allen BG, Bhatia SK, Buatti JM, Brandt KE, Lindholm KE, Button AM et al