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access is limited to approved clinical trials, and no EAMS designation has been granted, so adverse events must be reported through trial pharmacovigilance processes rather than Yellow Card
In some cases, this may influence the effectiveness of oral contraceptives or hormone replacement therapy
However, by improving metabolic control and reducing insulin spikes, it may indirectly reduce metabolic stress that can worsen hot flash intensity
Cycle length depends on the research goal and tolerability
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