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The populations studied ranged in size from 3297 (SUSTAIN-6) to 14,752 (EXSCEL), were of similar age (mean age was 64.0 1.97 years), 37,117 were male (62.8%), and the median duration of follow-up ranged from 1.3 to 5.4 years
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The shape parameter () was 0.63, and the upper limit of its 95% confidence interval (CI) was 0.66, indicating a decrease in the incidence of ADEs over time (Figure 5B)
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