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In humans, dietary l-carnitine is converted into the atherosclerosis- and thrombosis-promoting metabolite TMAO via 2 sequential gut microbiotadependent transformations: (a) initial rapid generation of the atherogenic intermediate BB, followed by (b) transformation into TMA via low-abundance microbiota in omnivores, and to a markedly lower extent, in vegans/vegetarians
Presented for research literature review only Seeley RJ et al
45,46 In contrast, anorexigenic neurons suppress appetite by expressing proopiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) peptide
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