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A protein restricted diet without calorie restriction does not affect the IGF-1 axis To assess the impact of an isocaloric PR diet on serum IGF-1 and IGFBPs levels, a total of 38 overweight (BMI 30.5 5.5 kg/m 2 ) adult males (59 7 years old) adhered to either a calorie-customized 8% protein diet ( n = 19) or a control diet ( n = 19) for 43 11 days (Fig
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To the reporters of the investigation, McGuire was more direct: the compound should not be used by humans. Eric Topol, director of the Scripps Research Translational Institute, was even more straightforward than McGuire: None of [the experimental compounds] are proven. He called it extraordinary that gray market human use was occurring in the absence of adequate clinical trials
Phase II clinical trials in humans showed that AOD-9604 produced statistically significant weight loss compared to placebo over 12 weeks
