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According to clinical trials and the Wegovy SmPC, semaglutide commonly causes nausea (occurring in up to 44% of patients), vomiting (approximately 25%), diarrhoea (30%), constipation, and abdominal discomfort, particularly during dose escalation
A landmark randomized, double-blind, placebo-controlled Phase 2 study conducted in the United States enrolled 338 adults with obesity or overweight conditions across multiple dosing regimens
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