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MOTS-c is a mitochondrial-derived peptide that activates AMPK through direct mitochondrial signaling and nuclear translocation under metabolic stress, whereas metformin activates AMPK indirectly by inhibiting Complex I of the mitochondrial electron transport chain, and AICAR mimics AMP to trick the cell into AMPK activation

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DHT and Androgen Sensitivity Androgenetic alopecia is driven primarily by dihydrotestosterone (DHT) binding to androgen receptors in follicular cells, causing progressive miniaturization

Of these, 84% were women, with a median BMI of 42 kg/m 2 at the time of bariatric surgery