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Position 8 alanine is replaced with -aminoisobutyric acid (Aib), an unnatural amino acid that completely blocks dipeptidyl peptidase-IV (DPP-IV) cleavage of the Tyr1Ala2 bond
J Clin Invest (1984) 73:177284.10.1172/JCI111386 5 VillaPSaccaniASicaAGhezziP
doi: 10.1016/j.bbacli.2016.05.006 26 SaundersJ
Through its involvement in cellular growth signaling and protein synthesis pathways, IGF-1 LR3 has been widely studied in research settings focused on muscle hypertrophy, tissue repair, recovery, and metabolic efficiency
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