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Heres a breakdown of the most commonly reported side effects: Less common but more serious side effects may include: Its also essential to note that GLP-1 receptor agonists are not suitable for everyone

Gilead Pipeline at a Glance Updated: May 21, 2026 Clinical stage programs* Opt-in Programs Phase 1 Phase 2 Phase 3 Therapeutic Areas Trial Phase x Understanding Pipeline Terms Phase 2 Phase 3 Opt-in Programs Phase 1 Phase 2 Phase 2 Phase 2 clinical trials study efficacy while also collecting data about safety

Another meta-analysis of patients with type 2 diabetes, overweight or obesity also found that when oral hypoglycemic drugs, insulin or lifestyle interventions were used as controls, there was no significant difference in the effect of GLP-1RAs on lean mass and lean mass percentage [57]

Unlike many diabetes medications, Metformin doesn't increase insulin secretion