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Matt Kaeberlein (UW Medicine, Optispan) observed: Expecting a single drug to meaningfully alter the course of Alzheimers once cognitive decline is underway is an extraordinarily high bar. The EVOKE population already had MCI or mild dementiameaning pathological cascades were well-established

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For the receptor-signaling background that these melanocortin analogs share, our reference on MC1R signaling in pigmentation research covers the pathway in depth