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Together, the FLOW and SELECT trials underscore the potential of GLP-1RAs to address multimorbidity in CKD by impacting obesity, cardiovascular disease, and kidney health

This difference is due to significant differences in their metabolic characteristics: Tregs generate NADPH through the fatty acid oxidation (FAO) pathway (dependent on malate dehydrogenase and IDH1), maintaining a high GSH/GSSG ratio to resist lipid peroxidation

Accessed at www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss