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[28]Edwards BA, Kushner DS, et al

We call this a caffeine crash, and its the reason you could feel even more drowsy a few hours after drinking a caffeinated beverage

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Inflammatory factors (e.g., TNF-, IL-6) and ROS associated with IBD impair the capacity of cells to repair lipid peroxidation by inhibiting the activity or expression of GPX4, synergizing with iron overload to significantly lower the threshold for epithelial cells to undergo ferroptosis