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An important number of nuclear proteins, including transcription factors, require a reduced environment to bind to DNA
The gut and brain talk constantly along the vagus nerve and through immune, hormonal and short-chain-fatty-acid signals the microbiotagutbrain axis and a disturbed microbiome in IBS (which affects 1020% of people), SIBO , leaky gut or long COVID can cloud thinking
Avoid both injectable and topical use in these populations without clinician oversight
Typical dosages explored in human pilot studies range from 5mg to 10mg, administered several times per week
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