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Insulin Resistance While IGF-1 can enhance insulin sensitivity in the short term, chronic exposure to elevated IGF-1 levelsparticularly with IGF-1 LR3 can eventually cause the opposite effect: Downregulation of insulin receptors Impaired glucose uptake Elevated fasting blood sugar levels This risk is amplified when IGF-1 is stacked with HGH , insulin , or consumed with a high-calorie, high-carb diet