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In addition, BDNF up-regulates the expression of voltage-gated Ca 2+ and Na + channels at the plasmamembrane [4]
Its not yet FDA-approved but widely administered by trained practitioners
Contact Dermatitis 71, 191201 (2014)
Stronger mechanistic clarification would require isoform-specific NOS inhibition, direct measurement of NO metabolites, eNOS phosphorylation analysis, rescue experiments, and comparison across endothelial, epithelial, fibroblast, and neuronal model systems
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