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As with any blend, the position to state plainly is that the combination itself has not been studied: no published work has examined these four compounds co-administered, and no synergy among them has been demonstrated
Although glitazone therapy can reduce cardiovascular events in selected populations [129], these agents also increase the risk of clinically apparent heart failure and of fractures [129, 130], which in turn may reduce physical function and worsen sarcopenia
Glutathione peroxidases regulate insulin signaling (GPx1) (McClung et al., 2004), NF-B activation (GPx1 and 4) (Kretz-Remy et al., 1996
Senile osteoporosis has become a major global public health problem with an increasing number of fractures, disabilities and high socio-economic costs
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