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Acne is not a sign of poor personal hygiene
Conclusion Addition of pioglitazone 30 mg/day to T2DM patients who did not reach the target HbA1c (7%) with treatment of dapagliflozin 10 mg/day and metformin over 1,000 mg/day showed effective glucose lowering efficacy without significant hypoglycemia and good tolerability with low prevalence of edema in spite of modest weight gain
A wide range of non-motor manifestations, including hyposmia or anosmia, gastrointestinal disturbances like chronic constipation, rapid eye movement (REM) sleep behavior disorder, autonomic dysfunction, mood changes like depression and anxiety, and progressive cognitive impairment, account for a significant portion of the disease burden [3]
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