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This release of secondary messenger molecules, such as IP3, might potentially stimulate the discharge of calcium ions (Ca2+) from the cells internal stores

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While clinical validation of this mechanistic advantage continues to evolve, the dual-inhibition profile positions Polmacoxib as a promising therapeutic option for managing osteoarthritis

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Modanloo M, Shokrzadeh M (2019) Analyzing mitochondrial dysfunction, oxidative stress, and apoptosis: potential role of L-carnitine

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