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Activation of POMC neurons leads to the release of alpha-melanocyte-stimulating hormone (-MSH), which subsequently binds to the melanocortin 4 receptor in the paraventricular nucleus of the hypothalamus and triggers appetite-inhibiting signaling cascade
Researchers gave 32 men with ED a combination of intranasal PT-141 (either 7.5 or 10 mg) plus oral sildenafil (50 or 100 mg), then used a RigiScan device to objectively measure erectile rigidity over 6 hours.Impressively, adding PT-141 to sildenafil increased the duration of erectile activity by over five-fold compared to sildenafil alone
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