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Unlike full-length growth hormone, which can cause edema (fluid retention), joint pain, carpal tunnel syndrome, glucose elevation, and increased IGF-1, AOD-9604 demonstrates none of these effects in clinical trials
The evening timing (before bedtime) is recommended to leverage the bodys natural night-time GH peak and to reduce daytime inconvenience
Whilst some studies found beneficial effects in patients with AD 36 and dementia 90 and in shift workers, 91 others found no improvements in patients with sleepwake rhythm disorders
doi:10.1016/j.yrtph.2020.104665 Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JHS
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