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Research article Peer reviewed People Animals

Studies have shown that when amyloid-beta and tau are increased, the cells ability to neutralize oxidative stress and mitochondria specific ROS is decreased leading to further tau hyperphosphorylation and neurodegeneration ( These redox imbalances also impact astrocytes, which normally synthesize GSH through the consecutive sections of two ATP consuming cytosolic enzymes

Calderone and others (22) demonstrated that zinc plays an integral role in this regulation through its persistent downregulation of GluR2 mRNA (22)

10.1016/j.tem.2011.12.008 12 FrosstP.BlomH.MilosR.GoyetteP.SheppardC.MatthewsR.et al