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SubQ adipose tissue tolerates up to 3 mL per site, and larger total volumes can be split across multiple SubQ sites (e.g., 2 mL abdomen + 1.5 mL thigh) without compromising pharmacokinetics

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On the other hand, it is thought that the different findings observed between in vivo and in vitro may be due to the complexity of the tumor microenvironment (TME)