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In the proteinprotein interaction (PPI) network, we obtained that Nrf2 regulates ferroptosis primarily by directly affecting the synthesis and function of GPX4 and the peroxisome proliferator-activated receptor gamma (PPAR) pathway, and we hypothesize that the regulation of intracellular iron concentration by Nrf2 is mainly through the Nrf2HO-1 axis
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BPC-157 demonstrates an exceptional safety profile in available research, with minimal reported adverse effects across numerous studies
PMID: 41138283 | doi:10.1016/j.jpba.2025.117207 Rahman OF et al
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