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Semaglutides effect on gastric emptying actually contributes to its effectiveness for weight management by promoting satiety, but this same mechanism causes most gastrointestinal side effects
Only small amounts reach your bloodstream intact, limiting practical benefit for most people
The supplements independent effectiveness without lifestyle changes is unclear
In the first NEJM study, there was a higher risk of pancreatic inflammation in the semaglutide group (2% v 1.2% placebo for gallstones) however all recovered
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