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Heres what the results look like compared to semaglutide and tizepatide: In a 2023 study by Yale University School of Medicine, researchers gave 338 adults a weekly injection of retatrutide or placebo for 48 weeks
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Patients on diuretics (particularly thiazides or loop diuretics) face amplified dehydration risk
Depending on your treatment duration, biomarker response, and clinical goals, providers may recommend slow dose reduction over 48 weeks, concurrent lifestyle intensification, or transition to alternative metabolic support
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